Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk
نویسندگان
چکیده
منابع مشابه
UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk.
Estrogen exposures play a critical role in the development of endometrial cancer. Genetic variation in the estrogen metabolism UGT1A1 gene may modify the effect of estrogenic exposures on endometrial cancer risk. We tested this hypothesis in a population-based case-control study of 1,047 endometrial cancer cases and 1,035 controls who completed an in-person interview and were genotyped for the ...
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15 صفحه اولThe functional UGT1A1 promoter polymorphism decreases endometrial cancer risk.
UDP-glucuronosyltransferase (UGT) 1A1 is involved in the inactivation of estradiol (E(2)) and its oxidized metabolites. These metabolites have been shown to contribute to the development of endometrial cancer in animal studies. Thus UGT1A1 represents a candidate gene in endometrial carcinogenesis. In this study, we established the substrate specificity of UGT1A1 for E(2) and its 2- and 4-hydrox...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2009
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e328323f66c